Transient response for interaction of two dynamic bodies

During the launch sequence of any space vehicle complicated boundary interactions occur between the vehicle and the launch stand. At the start of the sequence large forces exist between the two; contact is then broken in a short but finite time which depends on the release mechanism. The resulting vehicle response produces loads which are very high and often form the design case. It is known that the treatment of the launch pad as a second dynamic body is significant for an accurate prediction of launch response. A technique was developed for obtaining loads generated by the launch transient with the effect of pad dynamics included. The method solves uncoupled vehicle and pad equations of motion. The use of uncoupled models allows the simulation of vehicle launch in a single computer run. Modal formulation allows a closed-form solution to be written, eliminating any need for a numerical integration algorithm. When the vehicle is on the pad the uncoupled pad and vehicle equations have to be modified to account for the constraints they impose on each other. This necessitates the use of an iterative procedure to converge to a solution, using Lagrange multipliers to apply the required constraints. As the vehicle lifts off the pad the coupling between the vehicle and the pad is eliminated point by point until the vehicle flies free. Results obtained by this method were shown to be in good agreement with observed loads and other analysis methods. The resulting computer program is general, and was used without modification to solve a variety of contact problems

The economic debate on power: A Marxist critique

In the economic debate on power, seemingly opposite positions have been presented. Contractualists have claimed that power relations do not exist in capitalism, and radicals have maintained that they are ubiquitous. In the middle, transaction costs and property rights economists have argued that power relations exist only within the firm. The underlying conception, however, is the same: power is an interpersonal relation caused by imperfections in the decision-making context and is incompatible with Walrasian competition. The difference among these theories involves their viewpoints on the concrete spread of imperfections in reality. The thesis of this paper is that this narrow conception of power is a consequence of neoclassical methodology. Following Marx, I analyze power as a social relation, and I discuss three problematic aspects of the neoclassical conception: its individualistic methodology, the assumption of universal rather than historical categories, and an ontology that conflates production and circulation

THE CRISIS OF INSTITUTIONS AND PENAL MEDIATION. FRENCH AND SPANISH EXPERIENCES

The age of globalization, in its second and third phase (the second one already ended within the twentieth century) – which witnesses the full deployment of the productive and commercial potentialities of humanity – breaks the “boundaries” of the relationship between individual and institutions. In addition, these epochal circumstances spread a feeling of “disorientation” fueled, in turn, by the widespread complexity of heterogeneous and sometimes contradictory values. In individualistic societies, the collective forms of control must give way to individual and individualized forms, which impact on the individual. Often, the latter are tools that exist or are born within the social context, which are disconnected from the institutional network and aimed at helping people to manage the relational conflicts that enmesh them. In this context, mediation – precisely because it is born as experience and social practice and constitutes an adequate response to the needs of the individual – can represent a new (at least for the law) and different modality of conflict regulation. This alternative modality allows institutions to move closer to the individual, recovering the dual capacity and function of promoting individual liberties and guaranteeing social order. This research focuses on penal mediation, starting from the origin of the idea of community mediation, to get to the analysis of cases of penal mediation in France and in Spain. The main idea is that mediation can be used in all the systems in which the conflictual dynamics are manifested and that sometimes it is institutionalized for further and different purposes

Transition from a simple yield stress fluid to a thixotropic material

From MRI rheometry we show that a pure emulsion can be turned from a simple yield stress fluid to a thixotropic material by adding a small fraction of colloidal particles. The two fluids have the same behavior in the liquid regime but the loaded emulsion exhibits a critical shear rate below which no steady flows can be observed. For a stress below the yield stress, the pure emulsion abruptly stops flowing, whereas the viscosity of the loaded emulsion continuously increases in time, which leads to an apparent flow stoppage. This phenomenon can be very well represented by a model assuming a progressive increase of the number of droplet links via colloidal particles.Comment: Published in Physical Review E. http://pre.aps.org/abstract/PRE/v76/i5/e05140

Cluster of legionnaires’ disease in an Italian prison

Background: Legionella pneumophila (Lp) is the most common etiologic agent causing Legionnaires’ Disease (LD). Water systems offer the best growth conditions for Lp and support its spread by producing aerosols. From 2015 to 2017, the Regional Reference Laboratory of Clinical and Environmental Surveillance of Legionellosis of Palermo monitored the presence of Lp in nine prisons in Western Sicily. During this investigation, we compared Lp isolates from environmental samples in a prison located in Palermo with isolates from two prisoners in the same prison. Methods: We collected 93 water samples from nine Sicilian prisons and the bronchoalveolar lavages (BALs) of two prisoners considered cases of LD. These samples were processed following the procedures described in the Italian Guidelines for the Prevention and Control of Legionellosis of 2015. Then, genotyping was performed on 19 Lp colonies (17 from water samples and 2 from clinical samples) using the Sequence-Based Typing (SBT) method, according to European Study Group for Legionella Infections (ESGLI) protocols. Results: Lp serogroup (sg) 6 was the most prevalent serogroup isolated from the prisons analyzed (40%), followed by Lp sg 1 (16%). Most of all, in four penitentiary institutions, we detected a high concentration of Lp >104 Colony Forming Unit/Liter (CFU/L). The environmental molecular investigation found the following Sequence Types (STs) in Lp sg 6: ST 93, ST 292, ST 461, ST 728, ST 1317 and ST 1362, while most of the isolates in sg 1 belonged to ST 1. We also found a new ST that has since been assigned the number 2451 in the ESGLI-SBT database. From the several Lp sg 1 colonies isolated from the two BALs, we identified ST 2451. Conclusions: In this article, we described the results obtained from environmental and epidemiological investigations of Lp isolated from prisons in Western Sicily. Furthermore, we reported the first cluster of Legionnaires’ in an Italian prison and the molecular typing of Lp sg 1 from one prison’s water system and two BALs, identified the source of the contamination, and discovered a new ST

RELAP5-3D thermal hydraulic analysis of the target cooling system in the SPES experimental facility

The SPES (Selective Production of Exotic Species) experimental facility, under construction at the Italian National Institute of Nuclear Physics (INFN) Laboratories of Legnaro, Italy, is a second generation Isotope Separation On Line (ISOL) plant for advanced nuclear physic studies. The UCx target-ion source system works at temperature of about 2273 K, producing a high level of radiation (10^5 Sv/h), for this reason a careful risk analysis for the target chamber is among the major safety issues. In this paper, the obtained results of thermofluid-dynamics simulations of accidental transients in the SPES target cooling system are reported. The analysis, performed by using the RELAP5-3D 2.4.2 qualified thermal-hydraulic system code, proves good safety performance of this system during different accidental conditions

Polarization as a signature of local parity violation in hot QCD matter

We show that local parity violation due to chirality imbalance in relativistic nuclear collisions can be revealed by measuring the projection of the polarization vector onto the momentum, i.e. the helicity, of final state baryons. The proposed method does not require a coupling to the electromagnetic field, like in the Chiral Magnetic Effect. By using linear response theory, we show that, in the presence of a chiral imbalance, the spin 1/2 baryons and anti-baryons receive an additional contribution to the polarization along their momentum and proportional to the axial chemical potential. The additional, parity-breaking, contribution to helicity can be detected by studying helicity-helicity azimuthal angular correlation

The role of microRNA in head and neck cancer: Current knowledge and perspectives

Head and neck cancer is one of the most commonly diagnosed malignancies worldwide. Patients with advanced disease stages frequently develop recurrences or distant metastasis, which results a five-year survival rates of less than 60% despite considerable advances in multimodality therapy. A better understanding of molecular basis of tumorigenesis is required to improve clinical outcomes and to develop new anti-cancer drugs. microRNAs (miRNAs) are a class of small, non-coding, RNA molecules that modulate gene expression post-Transcriptionally. They are important regulator in normal biological process; however miRNAs deregulation has been observed in many different tumors and is involved in tumorigenesis. miRNAs may act as tumor suppressors or as oncogenes. Several studies on head and neck cancer demonstrated how aberrant expression of miRNAs is involved in proliferation, metastasis, chemoresistence, and radioresistance. In addition, miRNAs are excellent biomarker targets because they circulate stable in human body fluids and can be obtained with non-invasive methods. Moreover, miRNAs up and down regulation has been correlated with specific cancer phenotype (poor prognosis, aggressiveness and resistance to treatment), playing a role as prognostic biomarkers. This review summarizes current finding on miRNAs in head and neck cancer and their potential role as target for next drug therapy. © 2014 by the authors

Polarization as a signature of local parity violation in hot QCD matter

We show that local parity violation due to chirality imbalance in relativistic nuclear collisions can be revealed by measuring the projection of the polarization vector onto the momentum, i.e. the helicity, of final state baryons. The proposed method does not require a coupling to the electromagnetic field, like in the Chiral Magnetic Effect. By using linear response theory, we show that, in the presence of a chiral imbalance, the spin 1/2 baryons and anti-baryons receive an additional contribution to the polarization along their momentum and proportional to the axial chemical potential. The additional, parity-breaking, contribution to helicity can be detected by studying its dependence on the angle with respect to the reaction plane or with helicity-helicity angular correlation.Comment: 5 pages, 4 pages of supplementary material, 3 figures; some minor additions to the text and added reference